Reproductive Medicine & IVF

What To Know About the Causes of Infertility, Evaluation and Treatment

Preparation can help clinicians deftly address patient questions and concerns about diagnosis, treatment and causes of infertility.

Fertility is often a common concern for people in their reproductive years. These patients may have questions about diagnoses, treatments and causes of infertility. It is important for physicians to validate these concerns by finding answers if possible. Clinically, infertility is defined as the inability to achieve pregnancy after one year of having unprotected intercourse. However, that timeframe drops to six months for people ages 35 or older.

Gynecologists play an integral role in helping patients navigate the often confusing and emotional subject of infertility diagnosis and treatment, so it pays to be knowledgeable about these issues. Consulting with specialists in reproductive medicine may also be helpful.

Infertility Can Have Multiple Potential Causes

What causes infertility? In many cases, the specific cause of infertility is unknown, a condition called idiopathic infertility. In other cases, infertility can have multiple causes — and it can be just as likely to affect a male partner as a female one. While the factors influencing fertility can be far-ranging, common causes of infertility include:

For many couples, infertility may be the result of a combination of these infertility causes.

Uncovering and Diagnosing Infertility

Gynecologists and other health professionals typically begin the process of diagnosing infertility in women with a thorough medical history and physical exam. They may also use a variety of tests and exams, such as:


3D saline infusion ultrasound - uterine polyps

Physicians usually evaluate male fertility through a medical history, a physical exam and various blood tests.

Treatment Options

Treatment for infertility depends on the cause. According to the American Society for Reproductive Medicine, in the vast majority of cases — about 85 to 90 percent — infertility is treatable with conventional medical approaches, such as medication or surgery. The overall likelihood of successful treatment is about 50 percent, with treatment for problems involving ovulation the most apt to be successful.

Female infertility treatment options may include:

  • Medications to stimulate ovulation such as clomiphene, letrozole, gonadotropin and bromocriptine
  • Surgery to repair damage to or remove blockages from the fallopian tubes
  • Surgery to treat endometriosis, uterine fibroids, polyps or scarring

If infertility treatments have failed to address the problem, patients may wish to pursue assisted reproductive technologies such as intrauterine insemination, in vitro fertilization, sperm or egg donation or surrogacy.