IOTA Risk Assessment Models
Ovarian tumor analysis with Voluson™
SIMPLE RULES RISK CALCULATOR
Pre-operative classification system for ovarian tumors
The Simple Rules consist of five features typical for benign tumors (B-features) and five features typical for malignant tumors (M-features). Tumors are classified as Benign, Malignant or Inconclusive:
- Benign: Only B-features apply
- Malignant: Only M-features apply
- Inconclusive: No features apply,
- or both B- and M-features apply
Timmerman D, Van Calster B, et al. Am J Obstet Gynecol 2016;214:424-437.
LR2 RISK MODEL
Estimates probability of malignancy
LR2 uses six predictors (one clinical, plus five ultrasound):
- Age
- Maximal diameter of the largest solid component
- Irregular internal cyst walls
- Presence of papillary projections with detectable flow acoustic shadows
- Ascites
The algorithm produces a % of probability.
Timmerman D, et al. J Clin Oncol 2005;23:8794-801.
ADNEX RISK MODEL
Estimates probability a tumor is benign, borderline, stage 1 cancer, stage II-IV cancer or secondary metastatic cancer
The ADNEX model uses nine predictors (three clinical, six ultrasound):
- Age
- Serum CA-125 level
- Type of center
- Maximal diameter of lesion
- Proportion of solid tissue
- 10 cyst locules
- # of papillary projections
- Acoustic shadows
- Ascites
The algorithm produces a % for various tumor types.
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August 2019
JB69323XX