IOTA Risk Assessment Models
Ovarian tumor analysis with Voluson™
SIMPLE RULES RISK CALCULATOR
Pre-operative classification system for ovarian tumors
• Benign: Only B-features apply
• Malignant: Only M-features apply
• Inconclusive: No features apply,
or both B- and M-features apply
![Risk Calculator](/data/pages/guidelines/Iota-risk/Risk_Calculator.png)
Timmerman D, Van Calster B, et al. Am J Obstet Gynecol 2016;214:424-437.
LR2 RISK MODEL
Estimates probability of malignancy
• Age
• Maximal diameter of the largest solid component
• Irregular internal cyst walls
• Presence of papillary projections with detectable flow acoustic shadows
• Ascites
The algorithm produces a % of probability.
![Risk Model](/data/pages/guidelines/Iota-risk/Risk_Model.png)
Timmerman D, et al. J Clin Oncol 2005;23:8794-801.
ADNEX RISK MODEL
Estimates probability a tumor is benign, borderline, stage 1 cancer, stage II-IV cancer or secondary metastatic cancer
The ADNEX model uses nine predictors (three clinical, six ultrasound):
• Serum CA-125 level
• Type of center
• Maximal diameter of lesion
• Proportion of solid tissue
• > 10 cyst locules
• Acoustic shadows
• Ascites
The algorithm produces a % for various tumor types.
![ADNEX RISK MODEL](/data/pages/guidelines/Iota-risk/Adnex_Risk_Model_left.png)
![ADNEX RISK MODEL](/data/pages/guidelines/Iota-risk/Adnex_Risk_Model_right.png)
![Stages](/data/pages/guidelines/Iota-risk/Stages.png)
![Table of Lesions](/data/pages/guidelines/Iota-risk/Table_of_lesions.png)
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GE Healthcare reserves the right to make changes in specifications and features shown herein, or discontinue the product described at any time without notice or obligation. Contact your
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Company. GE Medical Systems, Inc., doing business as GE Healthcare.
August 2019
JB69323XX